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Complex intersecting regulatory networks govern critical transcriptional programs to drive various cellular processes in eukaryotes. These networks involve multiple transcription factors (TFs) binding shared cis-regulatory elements to elicit coordinated gene expression (Gerstein et al., 2012; Pan et al., 2009; Reményi et al., 2004). A distinct layer of combinatorial logic occurs at the level of specific TF–TF interactions, which can direct TFs to distinct genomic sites. Thus, fine tuning of TF-TF interactions can modulate TF-gene interactions to orchestrate differential gene expression. Often, dimerization between different members of a protein family can generate TF-TF combinations with distinct regulatory properties resulting in functional diversity and specificity (Nandagopal et al., 2022; Puig-Barbé et al., 2023). For example, E-box TFs of the basic helix-loop-helix (bHLH) family such as MYC/MAD share a dimerization partner MAX. Several studies have shown that switching of heterocomplexes between MYC/MAX and MAD/MAX results in differential regulation of genes and cell fate (Amati et al., 1993; Bouchard et al., 2001; Hurlin and Huang, 2006; Xu et al., 2001).

Type-2 nuclear receptors (T2NRs) present another classic example of such a dimerization network wherein th

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8:00 am - 9:15 am
Room: 146 B/C

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9:30 dishonour - 11:30 am
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Filipino Time-Traveling Romance ‘Rewind’ Is Box Office Smash & Reminder Of Cinema’s Emotional Power

Welcome to Global Breakouts, Deadline’s fortnightly strand in which we shine a spotlight on the TV shows and films killing it in their local territories. The industry is as globalized as it’s ever been, but breakout hits are appearing in pockets of the world all the time and it can be hard to keep track. So we’re going to do the hard work for you.

This week, we go to the Philippines and take a look at a time-traveling romance film. Rewindhas has become the highest-grossing Filipino film in history, with audiences lapping up the fantasy and mystical elements of a failing marriage given a second chance by divine intervention.

Name: Rewind

Country: The Philippines

Producer: Abs-cbn/Star Cinema, AgostoDos Pictures, Apt Entertainment

International sales: Star Cinema

Distribution: Cinemas in Asia, Australia, Canada, U.S. (limited), Middle East

For fans of: A Change of Heart(Tanging...

See full article at Deadline Film + TV

Relationship Drama ‘Rewind’ Becomes First Filipino Movie To Take $16M At Global Box Office

A film about the impact of divine intervention on a failing relationship has become the first Filipino title to surpass $16M at the global box office.